The clinical value of combined detection of plasma Lp -PLA2 and D -dimer in patients with hypertension complicated with stroke
10.3760/cma.j.issn.1008-6706.2017.04.011
- VernacularTitle:联合检测血浆脂蛋白磷脂酶 A2、D-二聚体对高血压患者并发脑卒中的价值
- Author:
Kun WANG
;
Changxin ZHAO
;
Ying ZHANG
;
Fumeng YANG
;
Jiandong JIANG
;
Jinxia CAO
;
Tinglu ZHANG
- Keywords:
Hypertension;
Apoplexy;
Plasma lipoprotein phospholipase A2;
D -dimer
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(4):522-525
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of plasma lipoprotein phospholipase A2 (Lp -PLA2 )and D -dimer in patients with hypertension complicated with stroke.Methods 70 hypertensive patients with stroke were selected as A group,72 patients with simple hypertension were selected as B group,and 71 healthy sub-jects were selected as C group.The light transmitting method was used to detect serum Lp -PLA2 ,and immunoturbi-dimetry was used to detect plasma D -dimer.The clinical value of the two joint detection and single detection in prediction of hypertension complicated with stroke was analyzed.Results The plasma Lp -PLA2 and D -dimer levels of A group were (471.88 ±181.49)ng/mL,(982.54 ±373.28)μg/mL,which were higher than those of B group[(195.17 ±34.74)ng/mL,(263.57 ±29.70)μg/mL]and C group[(122.94 ±46.25)ng/mL,(96.44 ± 8.49)μg/mL](F =189.7,171.1,all P =0.000).The plasma Lp -PLA2 level of A group was positively correlated with D -dimer(r =0.692,P <0.01).The plasma D -dimer >252g/mL forecast hypertension stroke risk sensitivity was 83.3% and specificity was 98.6%,the plasma Lp -PLA2 >176.36ng/mL forecast hypertension stroke risk sen-sitivity was 92.9% and specificity was 83.1%,and the combined prediction of hypertension stroke risk sensitivity was 87.6%,specificity was 93.5%.Conclusion The plasma levels of Lp -PLA2 and D -dimer are significantly increased in hypertensive patients with stroke,and the combined detection of the two indicators can improve the prediction of stroke risk in patients with hypertension.
