Clinical effect and influence of sequential therapy on serum levels of IL-10 and TNF-αin children with ;peptic ulcer
10.3760/cma.j.issn.1008-6706.2017.02.010
- VernacularTitle:序贯疗法对消化性溃疡患儿的临床疗效及对白细胞介素-10和肿瘤坏死因子-α表达水平的影响
- Author:
Lingling LUO
;
Yingrong LIN
;
Danfeng PAN
;
Jinbiao JIANG
- Keywords:
Peptic ulcer;
Interleukin-10;
Tumor necrosis factor-alpha;
Child
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(2):197-200
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy,adverse reactions and serum levels of IL -10 and TNF-αin children with peptic ulcer undergoing sequential therapy.Methods 68 children with peptic ulcer were selected and randomly divided into two groups,34 cases in each group.The control group received quadruple therapy, namely omeprazole,amoxicillin,clarithromycin and bismuch treatment for seven days.The treatment group underwent sequential therapy:the first 5 d of oral omeprazole,amoxicillin treatment,and the next 5 d omeprazole,amoxicillin and inidazole treatment.The clinical efficacy,adverse reactions,IL-10 and TNF-αlevels of the two groups were com-pared.Results The total effective rates after treatment of the control group and treatment group were 88.24% and 91.18% respectively,there was no statistically significant difference between the two groups(χ2 =1.21,P>0.05). After treatment,the levels of IL-10 and TNF-αin the control group were (24.93 ±6.29)pg/mL and (37.93 ± 8.28)pg/mL,which were significantly decreased (t=5.52,P<0.05,t=8.51,P<0.01).And the levels of IL-10 and TNF-αin the treatment group were (21.36 ±6.31)pg/mL and (29.67 ±6.38)pg/mL,which were significantly decreased(t=11.15,12.29,all P<0.01).The levels of IL-10 and TNF -αof the treatment group were much significant than those of the control group after the sequential therapy (t=3.32,P<0.05,t=8.71,P<0.01). Conclusion Sequential therapy for the treatment of children with peptic ulcer has better effect than the quadruple therapy,and can reduce serum IL-10 and TNF-αlevels,it is worthy of promoting.
