Preparation,Characterization and in vitro Dissolution Study of Total Flavonoids of Hippophae rhamnoi-des-PVP K30 Solid Dispersion
10.6039/j.issn.1001-0408.2017.01.30
- VernacularTitle:沙棘总黄酮-聚乙烯吡咯烷酮K30固体分散体的制备、表征及体外溶出研究
- Author:
Qian TIAN
;
Chen HE
;
Jingxia HE
;
Rongli YIN
;
Junxuan YANG
;
Li ZHANG
- Keywords:
Total flavonoids of Hippophae rhamnoides;
PVP K30;
Solid dispersion;
Dissolution rate;
Orthogonal test;
Charac-terization
- From:
China Pharmacy
2017;28(1):115-118
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare total flavonoids of Hippophae rhamnoides(TFH)-PVP K30 solid dispersion,and to char-acterize and study its in vitro dissolution. METHODS:Solvent method was used to prepare TFH-PVP K30 solid dispersion with dif-ferent drug-loading ratio of 1:1,1:2,1:3,1:4,1:5;single factor test was designed to screen drug-loading ratio using dissolution parameter Td as index;orthogonal test was designed to optimize ultrasonic time,temperature of water bath and drying time for prep-aration technology using in vitro dissolution rate as index,and then validated. SEM,DSC and FT-IR were used to characterize sol-id dispersion. RESULTS:Td of TFH-PVP K30 solid dispersion was the lowest when drug-loading ratio was 1:3. Optimal technolo-gy was ultrasonic time 10 min,temperature of water bath 60 ℃ and drying time 12 h. 90 min accumulative dissolution rate of pre-pared TFH-PVP K30 solid dispersion was 90.22% in average(RSD=1.74%,n=3). The results of SEM,DSC and FT-IR showed that the drug as amorphous form dispersed in the PVP K30,the formation of hydrogen bond of the both. CONCLUSIONS:TFH-PVP K30 solid dispersion is prepared successfully,and in vitro dissolution rate of it is improved significantly.
