Cellular and molecular mechanism of CD8 + T cell exhaustion
10.3760/cma.j.jssn.1673-4904.2016.12.020
- VernacularTitle:CD8+T细胞耗竭的细胞及分子机制研究进展
- Author:
Weina JIN
;
Minshu LI
;
Guoqiang CHANG
;
Jianping ZHOU
;
Xiaodong ZHU
;
Baocheng CHANG
- Keywords:
CD8-positive T-lymphocytes;
Infection;
Neoplasms;
Review
- From:
Chinese Journal of Postgraduates of Medicine
2016;39(12):1123-1127
- CountryChina
- Language:Chinese
-
Abstract:
T-cell exhaustion is characterized by the stepwise and progressive loss of T cell functions under conditions of antigen-persistence, which occurs following chronic infections and tumor outgrowth. Exhausted T cells present functional defects, express multiple inhibitory receptors and show reprogrammed transcriptional regulation. As T cell exhaustion is correlated to its dysfunction to control infections and tumors, exploring new strategies to target exhausted T cell may reverse this dysfunctional state and reinvigorate immune response. This study takes CD8+ T cell as an example, which acts as an important subset involved in exhaustion state, discuss current understanding of the properties of exhausted T cell and the mechanisms that promote and maintain this state, and reveal new therapeutic targets for chronic infection and cancer.
