The study of characteristic of serum Lp(a)level in in patients with chronic kidney disease
10.3760/cma.j.issn.1008-6706.2017.02.001
- VernacularTitle:慢性肾病患者血清脂蛋白a水平变化特点分析
- Author:
Qijian HUANG
;
Jin ZHANG
;
Decai QIAN
;
Hongfu ZHANG
;
Liang CHEN
;
Yajie WANG
;
Qiang WANG
;
Lamei LIAO
;
Yusong LIU
;
Rulan CHENG
;
Weijun ZHAO
;
Jihong LIU
;
Sheng LUO
;
Jun ZHENG
;
Jun LIU
;
Fangfang LI
;
Jianping HUANG
- Keywords:
Nephrosis;
Lipoprotein(a)
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(2):161-164
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristic of lipoprotein(a)[Lp(a)]in different phases of chronic kidney disease (CKD ),to provide the basis for clinical prevention and treatment of CKD.Methods 200 patients with CKD in the Republic Hospital of Shifang were collected as study group,including 5 phases (every phase had 40 cases),and 100 healthy people were selected as control group.Measured the serum Lp(a)of both study and control group,analyzed the correlations between Lp(a)and different phase of CKD.All data were analyzed by SPSS version 17.0.The significant level was established at 0.05.Results CKD1 [(146.0 ±95.5)mg/L]and all CKD group [(231.5 ±133.2)mg/L]had higher level of serum Lp(a)than the control group [(115.5 ±70.2)mg/L] (Z=-2.800,P<0.05 and Z=-7.922,P<0.05).CKD3 had higher Lp(a)level than CKD2(Z=-2.069,P<0.05 ),while there were no significant differences between each of the other two groups.CKD4 -5 [(325 .0 ± 194.7)mg/L]also had higher Lp(a)level than CKD1 -3 [(182.0 ±110.5)mg/L](Z=-4.439,P<0.05). Conclusion Patients with CKD always have high level of serum Lp(a),which have been slowly increased since CKD1 ,meanwhile the level of Lp(a)may have a certain correlation with the stage of CKD development,since Lp(a) is an important promoting factor in the progress of CKD.
