Study on the relationship between the level of immunoglobulin and the prognosis of viral infection in the cervical mucus of high risk type HPV infection
10.3760/cma.j.issn.1008-6706.2017.02.016
- VernacularTitle:高危型人乳头瘤病毒感染患者宫颈黏液免疫球蛋白水平与病毒感染转归的关系研究
- Author:
Qiuchan HUANG
- Keywords:
Humom papillmavirus;
Irrigation;
Immunoglobulin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(2):221-224
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the level of HPV (hs -HPV)infection in the cervical lavage fluid and the virus clearance.Methods 89 cases of hs -HPV infection were selected as research subjects.According to the different outcomes of 1 year,the patients were divided into persistent infection group (23 cases)and negative group (66 cases).The cervical lavage fluid immunoglobulin (IgA,IgM,IgG)in the two groups were detected,and 37 normal people were selected as control group.The relationship between cervical lavage protein immunoglobulin (IgA,IgM,IgG)level and the removal of hs-HPV was studied.Results Of 89 cases of different types of hs-HPV infection,16 type and 18 type accounted for 55.1%,20.2%;different type of hs-HPV infected cervical lavage fluid,the immunoglobulin IgA,IgM,IgG by the analysis of variance showed no significant difference (P<0.05),HPV16 [IgA(18.3 ±3.8)μg/mL,IgM(89.2 ±9.8)μg/mL,IgG(15.4 ±3.6)μg/mL], HPV18[IgA(17.7 ±4.2)μg/mL,IgM(90.5 ±9.6)μg/mL,IgG(15.2 ±3.0)μg/mL],other type [IgA(17.9 ± 4.0)μg/mL,IgM(92.1 ±8.4)μg/mL,IgG(15.6 ±3.7)μg/mL],mixed infection [IgA(18.4 ±3.9)μg/mL,IgM (93.6 ±9.4)μg/mL,IgG(15.2 ±3.5)μg/mL]were higher than those of the control group [IgA(14.6 ±2.6)μg/mL, IgM(81.3 ±8.5)μg/mL,IgG(11.2 ±2.3)μg/mL],the differences were statistically significant (F=6.547,6.928, 10.217,all P<0.05).Cervical lavage fluid immunoglobulin levels between the different outcomes of hs-HPV infec-tion,the normal control group,infection group and negative group IgA continued IgG,cervical lavage fluid concentra-tion gradually increased,IgM persistent infection group and negative group cervical lavage fluid (P>0.05 )concen-tration had no significant difference,persistent infection group [IgA(17 ±3.1)μg/mL,IgG(86.2 ±5.4)μg/mL,IgM (14.8 ±3.1)μg/mL].The negative group [IgA(18.6 ±3.6)μg/mL,IgG(93.8 ±6.7)μg/mL,IgM(15.8 ± 3.3)μg/mL]were higher than those of the normal control group [IgA(14.6 ±2.6)μg/mL,IgM(81.3 ±8.5)μg/mL, IgG(11.2 ±2.3)μg/mL],the differences were statistically significant (F=6.547,6.928,10.217,all P<0.05). Conclusion The immune defense of the vaginal mucosa is closely related to the high risk of HPV,especially the sIgA plays an important role in the outcome of infection.
