Memory retrieval-extinction paradigm and its application on drug addicts

VernacularTitle:记忆提取消退范式及其在毒品成瘾者中的应用
Author: Tang HAO
Keywords: Relapse; Conditioned reflex; Reconsolidation; Memory retrieval-extinction
From: Chinese Journal of Behavioral Medicine and Brain Science 2016;25(12):1138-1141
CountryChina
Language:Chinese
Abstract: Based on the traditional fear extinction training paradigm, the retrieval-extinction para-digm rewrites fear memory within the reconsolidation window,and reduces their fear response by decreasing the valence of fear stimulus. From the perspective of psychology,the main reason of addicts relapse is that the intensive memory of the painful experience inspired when protracted withdrawal symptoms of drug depend-ence. The reduction of the sensitivity of drug related memory, which is the key of drug detoxification is to change the memory caused by drug related cues. The retrieval-extinction paradigm provides no drug treatment and a new non-invasive model for addicts,and a new perspective to reduce the relapse rate,and to improve the quality of life of addicts. We can do empirical research which using memory retrieval-estinction paradigm on drug addicts in the future.The memory retrieval paradigm can be applied to empirical research in drug ad-dicts in future.