Preparation and in vitro Dissolution Investigation of Polygala fallax Rapidly Disintegrating Oral Tablets
10.6039/j.issn.1001-0408.2017.01.15
- VernacularTitle:黄花倒水莲口腔速崩片的制备及体外溶出行为考察
- Author:
Wei WU
;
Yeying LIU
;
Ying HUANG
;
Liping LIU
;
Liyuan LIAO
;
Xiaoqun DUAN
- Keywords:
Polygala fallax;
Rapidly disintegrating oral tablets;
Preparation;
Formulation optimization;
Orthogonal test;
Disso-lution rate
- From:
China Pharmacy
2017;28(1):57-60
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare Polygala fallax rapidly disintegrating oral tablets and investigate its in vitro dissolution. METHODS:The rapidly disintegrating tablets was prepared by direct powder compression method. Using disintegration time as in-dex,the ratio of stuffing bulking agent mannitol to disintegrating agent microcrystalline cellulose,the amount of drug extract,the amount of lubricant magnesium stearate and other influential factors were investigated by single factor test and orthogonal test. The drug dissolution effect of prepared tablet(using senegenin as substance control)was evaluated by in vitro dissolution test(using wa-ter as dissolution medium,paddle method). RESULTS:The optimal formulation was that the amount of drug extract was 15%;the ratio of mannitol to microcrystalline cellulose was 1.5:1;the amount of magnesium stearate was 1.0%. The disintegration time of prepared tablet was(31±4)s;tablet hardness was(3.4±0.2)kg;tablet friability was(0.23±0.07)%(RSD<0.11%,n=3). Ac-cumulative dissolution rate of total saponins was more than 90% within 5 min. The dissolution parameters T50 was equal to 0.84 min and Td was equal to 1.77 min. CONCLUSIONS:Polygala fallax rapidly disintegrating oral tablets will dissolve quickly and dis-integrate rapidly in aqueous solution.
