Clinical features and outcomes of seronegative rheumatoid arthritis in western China after one-year treatment with traditional disease modifying anti-rheumatoid drugs
10.7652/jdyxb201701018
- VernacularTitle:西部地区血清阴性类风湿关节炎临床特点及传统抗风湿药治疗1年的转归分析
- Author:
Jing LUO
;
Yanhua WANG
;
Bomiao JU
;
Xiaohong Lü
;
Dan PU
;
Yining SUN
;
Zhiming HAO
;
Lan HE
- Keywords:
rheumatoid arthritis;
seronegative;
clinical feature;
treatment outcome;
alkaline phosphatase;
outcome of treatment
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2017;38(1):88-91
- CountryChina
- Language:Chinese
-
Abstract:
ABSTRACT:Objective To investigate the clinical features of seronegative rheumatoid arthritis (RA)in western China and its outcomes after one-year treatment with disease modifying anti-rheumatoid drugs (DMARDs) so as to provide evidence for effective therapy.Methods We made a retrospective analysis of 240 RA patients treated in our department from May 2013 to June 2014.We compared the 47 seropositive and 25 seronegative RA patients in clinical features,laboratory parameters and outcomes after one-year DMARDs medication.Results The percentage of seronegative RA was 10.4% (25/240).The number of swollen small joints was significantly smaller in seronegative RA group (P<0 .0 1 ).Compared with those in seropositive RA,the level of hemoglobin was lower,the level of platelets was higher,and the level of alkaline phosphatase was lower in seronegative RA (P<0 .0 5 ).The remission rate was higher in seronegative RA group than in seropositive RA group after one-year DMARDs administration (P<0.05).Conclusion Seronegative RA is not rare in clinic.Even though seronegative RA patients often present fewer swollen small joints, it is difficult to distinguish between seronegative and seropositve RA just based on the clinical features.Besides,hematological damage is more severe in some patients with seronegative RA.Only after one-year treatment with DMARDs,the remission rate is higher in seronegative RA patients than in seropositve RA ones.
