Non-invasive method of blood hemoglobin measurement based on time-resolved transmission spectroscopy

VernacularTitle:基于时间分辨透射光谱的血液血红蛋白无创检测方法
Author: Yuan YUAN ; He HUANG ; Jichun YANG ; Meixiu SUN
Keywords: Time-resolved transmission spectroscopy; Blood hemoglobin; Non-invasive measurement
From: International Journal of Biomedical Engineering 2016;39(6):341-344
CountryChina
Language:Chinese
Abstract: Objective To theoretically study the non-invasive measurement method of blood hemoglobin in vivo based on the time-resolved approach combined with occlusion spectroscopy.Methods The dynamic dual wavelength time-resolved transmission was analyzed based on the artificial blood flow kinetics condition on a human finger model.The sensitivity of hemoglobin measurement was improved by Laplace transforming of time-domain data.The method was validated using hemoglobin with a mass concentration range of 6～16 g/dl.Results The simulation results showed that compared with the continuous wave method,the time-resolved method could provide higher detection sensitivity using Laplace transform parameter p =5 × 1010 s-1.Conclusions The sensitivity of hemoglobin measurement can be enhanced when early arriving photons are emphasized by Laplace transformingthe time-resolved transmission with a small positive parameter.