Left ventricular noncompaction and gene mutation
10.3760/cma.j.issn.1673-4408.2017.01.007
- VernacularTitle:左心室心肌致密化不全突变基因的研究进展
- Author:
Lishen SHAN
;
Xinyuan KANG
- Keywords:
Left ventricular noncompaction;
Gene mutation;
Genetic heterogeneity
- From:
International Journal of Pediatrics
2017;44(1):28-31
- CountryChina
- Language:Chinese
-
Abstract:
Left ventricular noncompaction(LVNC) is a relatively rare cardiomyopathy due to the cessa tion of endocardial and myocardial cells in the early embryo development.The disease mainly is involved in the left ventricle.LVNC is sporadic or familial genetic disease,which has obvious genetic heterogeneity.It is X linkage and autosomal dominant inheritance.The genetic characteristics of LVNC are not single inheritance,and its pathogenic gene and mutation site are diverse.It has been shown that LVNC has a close correlation with multiple gene mutations,and it is also overlap with the genes that caused other cardiomyopathy.In this paper,we will review the research progress of LVNC and related gene mutations.