Clinical Observation of Oxaliplatin,Mitomycin and Doxorubicin Combined with Three-dimensional Con-formal Radiotherapy for Patients with Lack of Blood Supply Hepatocellular Carcinoma
10.6039/j.issn.1001-0408.2017.06.08
- VernacularTitle:奥沙利铂、丝裂霉素和多柔比星联合三维适形放疗用于乏血供肝癌的临床观察
- Author:
Luqing CHEN
;
Zhiqiang GAO
;
Huiyun CHENG
;
Zhenyou SUN
;
Hongsheng GAO
;
Guanghui HE
;
Yunzheng ZHAO
- Keywords:
Lack of blood supply hepatocellular carcinoma;
Oxaliplatin;
Mitomycin;
Doxorubicin;
TACE;
Three-dimensional conformal radiotherapy;
Efficacy;
Safety
- From:
China Pharmacy
2017;28(6):749-752
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of oxaliplatin,mitomycin and doxorubicin combined with three-di-mensional conformal radiotherapy for patients with lack of blood supply hepatocellular carcinoma. METHODS:62 patients with lack of blood supply hepatocellular carcinoma who lose the opportunity of operation were randomly divided into control group(31 cas-es)and observation group(31 cases). Control group received puncture through the femoral artery by Seldiner,selectively interven-ing in hepatic arteries for DSA angiography,then intravenously injected 130 mg/m2 Oxaliplatin for injection via the catheter,once every 2 weeks+Mitomycin for injection 10 mg,intravenously,once every 1-3 week(s)+Doxorubicin for injection 1.2 mg/kg,once every 3 weeks,then giving Iodinated oil emulsifier and Gelatin sponge particle for hepatic artery embolization,appropriate Iodinat-ed oil emulsifier and Gelatin sponge particle once a month,for 3 times. Observation group was additionally received three-dimen-sional conformal radiotherapy 2 Gy,for 25-30 times with total dose of 50-60 Gy,once every 3 days. They were treated for 3-month. Clinical efficacy,the survival rate and median survival time after the first administration of drug for 1,2 and 3 years in 2 groups were observed,and the incidence of adverse reactions was recorded. RESULTS:The total effective rate,the survival rate and median survival time in 1,2 and 3 years in observation were significantly higher than control group,with statistical signifi-cance (P<0.05). The incidences of neutropenia,thrombocytopenia,hemoglobin decreased and radioactive disease in observation group were significantly higher than control group,with statistical significances(P<0.05). CONCLUSIONS:Oxaliplatin,mitomy-cin and doxorubicin combined with three-dimensional conformal radiotherapy have good efficacy for patients with hepatocellular lack of blood supply carcinoma,also can prolong the survival time,they show poor safety.
