Determination of Antibacterial Effect of Ofloxacin Eye Drop
10.6039/j.issn.1001-0408.2017.06.33
- VernacularTitle:氧氟沙星滴眼液的抑菌效力测定
- Author:
Hao LI
;
Yu ZOU
;
Fan ZHANG
;
Yajie ZHANG
- Keywords:
Ofloxacin eye drop;
Colony count;
Antibacterial effect test method
- From:
China Pharmacy
2017;28(6):841-843
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a method for the determination of antibacterial effect of Ofloxacin eye drop. METH-ODS:According to the requirements in Chinese Pharmacopoeia(2015 edition)antibacterial effect test,using Staphylococcus au-reus,Pseudomonas aeruginosa,Escherichia coli,Aspergillus niger and Candida albicans as test bacteria,colonycount method suit-ability test was conducted for Ofloxacin eye drop samples,the verified method was used to determine the number of viable bacteria at each time point,calculate the bacteria number of 1 mL in the sample and the number of bacteria at each time point and convert to lg value. RESULTS:Ofloxacin eye drop sample can reach the standard of antibacterial effectiveness of theB. CONCLU-SIONS:The method can effectively determine whether the antibacterial effect of Ofloxacin eye drop fits the standard.
