Changes of cerebral gray matter pre- and post-treatment in patients with schizophrenia
10.3969/j.issn.1674-8115.2017.02.014
- VernacularTitle:精神分裂症患者急性期药物治疗前后的脑灰质变化
- Author:
Qiong XIANG
;
Yingchan WANG
;
Dianming ZHU
;
Kaiming ZHUO
;
Zheng WANG
;
Yifeng XU
;
Dengtang LIU
- Keywords:
schizophrenia;
grey matter;
voxel-based morphometry;
antipsychotics;
magnetic resonance imaging
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2017;37(2):203-206
- CountryChina
- Language:Chinese
-
Abstract:
Objective · To observe the changes of cerebral gray matter pre- and post-treatment with short term drugs in patients with schizophrenia. Methods · T1-weighted brain MRIs were obtained on a 3T scanner in 21 controls and 27 subjects with schizophrenia who were not given antipsychotic medication. The controls and 21 schizophrenia patients received the second scan after 8 weeks of antipsychotic treatment. Voxel-based morphometry (VBM) were used to investigate the differences in gray matter (GM), mainly about the regional GM volumes. Results · GM volumes were significantly smaller in the patient group than those of healthy controls in left cerebellum posterior lobe , left and right parahippocampalgyrus, left middle temporal gyrus(P=0.000, voxels>50). GM volumes extensively decreased after 8 weeks of antipsychotic-treatment compared with pre-treatment in the superior, middle, and inferior temporal gyri, superior,middle and inferior frontal gyri, parahippocampa gyri, cingulate gyri, right supramarginal gyrus, right cerebellum posterior lobe, and right lingual gyrus(P=0.000, voxels>50). Conclusion · Short term antipsychotic treatment (8 weeks) may have adverse effects on the gray matter of patients with acute schizophrenia by reducing the volume of gray matter.
