Molecular biological properties of lncRNA and their regulatory functions in the development of central nervous system
10.3969/j.issn.1674-8115.2017.02.027
- VernacularTitle:LncRNA分子生物学属性及其在中枢神经系统发育中的调控作用
- Author:
Chufan XU
;
Lai JIANG
- Keywords:
lncRNA;
molecular biological property;
development of central neuronal system;
regulatory function
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2017;37(2):262-266
- CountryChina
- Language:Chinese
-
Abstract:
Long noncoding RNA (lncRNA) refers to RNA transcripts with more than 200 nucleotides in length, which plays regulatory roles directly in the form of RNA. Their functions are affected by their secondary structures, post transcriptional modification and so on. LncRNA can be classified to various subtypes with complicated mechanisms. In human-induced-pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), dynamic expression of some lncRNAs is detected during the neuronal differentiation, and a series of lncRNAs associated closely with the development process of the central nervous system (CNS) are found. This review summarizes the molecular biological properties of lncRNA and their regulatory functions in the development of the CNS, which is helpful to reveal the mechanisms of the pathogenesis and progression of certain neurological diseases and results in innovation of their diagnosis and treatment.
