Clinical Study on the Effect of Pre-intervention with Electroacupuncture on Oxidative Stress and Inflammatory Reaction in Hepatic Ischemia-reperfusion
10.13460/j.issn.1005-0957.2017.02.0175
- VernacularTitle:电针预处理对肝脏缺血再灌注后氧化应激和炎症反应影响的临床观察
- Author:
Wei TANG
;
Lan YUAN
- Keywords:
Acupuncture;
Electroacupuncture;
Pre-intervention;
Hepatic ischemia-reperfusion;
Oxidative stress;
Inflammatory reaction
- From:
Shanghai Journal of Acupuncture and Moxibustion
2017;36(2):175-179
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of pre-intervention with electroacupuncture on oxidative stress (OS) and inflammatory reaction after hepatectomy under portal occlusion.Method Thirty patients going to receive hepatectomy under Pringle's portal occlusion were randomized into an electroacupuncture group and a sham electroacupuncture group, 15 cases each. Three days prior to the surgery, the patients started to receive corresponding acupuncture or sham electroacupuncture treatment by selecting bilateral Riyue (GB24), Qichong (ST30) and Yanglingquan (GB34), once a day. The anesthesia method was general (inhalational and intravenous) anesthesia. Central venous blood was drawn before the surgery, and respectively 6 h, 24 h, 48 h and 72 h after the surgery to examine the OS-relatedparameters, superoxide dismutase (SOD) and malondialdehyde (MDA), as well as the inflammatory mediators, including tumor necrosis factor-α(TNF-α), interleukin (IL)-1, IL-6, and IL-10.Result Compared to the sham electroacupuncture group, the SOD activity significantly increased (241±11.4 U/mL,180±12.6 U/mL,P<0.05) and the MDA level significantly dropped in the electroacupuncture group at 6 h and 24 h after the surgery(11.0±0.8 mmol/L,10.0±0.9 mmol/L,P<0.05); there were no significant between-group differences in the rest indexes (P>0.05).Conclusion Pre-intervention with electroacupuncture can up-regulate the activity of SOD and down-regulate the level of MDA in patients after hepatic portal occlusion, and thus partially reduce OS, but it doesn't shownoticeable effecton inflammatory response.
