Preparation of Curcumin-Lysine Cocrystal and Solubility Comparison of Different Crystal Forms
- VernacularTitle:姜黄素赖氨酸共晶的制备及不同晶型溶解性对比
- Author:
Hui XU
;
Fangkun ZHANG
;
Zongliang CHI
;
Baochang CAI
- Keywords:
Curcumin;
Cocrystal;
Lysine;
Dissolution profiles
- From:
China Pharmacist
2017;20(2):208-212
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To develop a new cocrystal form to improve bioavailability and druggability of curcumin. Methods:Solvent crystallization was used to prepare curcumin-lysine cocrystal, and two crystal forms ( a and b) were obtained. The two cocrystal forms were characterized by elemental analysis, differential scanning calorimetry and X-ray diffraction. The dissolution profiles of the two crystal forms were detected and compared with that of curcumin. Results:Curcumin combined with lysine at a stoichiometry of 1: 1 to form the cocrystal with much better solubility than curcumin. Conclusion: Curcumin-lysine cocrystal has ideal druggability, which means the cocrystal can be a new chemical entity used for subsequent development.
