Correlation of ATP Binding Cassette Transporter A1 Gene Polymorphisms and Lower Extremity Athero-sclerotic Disease
- VernacularTitle:三磷酸腺苷结合盒转运体A1基因多态性与下肢动脉粥样硬化的相关性
- Author:
Xiaofeng LIN
;
Chengjia DAI
;
Xia LIAN
;
Yan FEI
- Keywords:
ATP binding cassette transporter A1 gene;
Polymorphisms;
Correlation study;
Lower extremity atherosclerotic disease
- From:
China Pharmacist
2017;20(2):242-245
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation of single nucleotide polymorphisms ( SNP) of ATP binding cassette transporter A1 gene (ABCA1) and lower extremity atherosclerotic disease (LEAD). Methods: The clinical data and peripheral blood were col-lected from 630 participants (314 LEAD cases and 316 normal controls) in Han population of Minnan. The 9 SNP genotypes in the ABCA1 gene were detected by Sequenom MassArray. Results:Among the 9 SNP genotypes, rs2980083 was rejected because it wasn' t in accordance with Hardy-Weinberg equilibrium. Obvious linkage disequilibrium was found between rs2066714 and rs2066715, rs1800976 and rs2246293, rs2246293 and rs2980083, and rs1800976 and rs2980083(D′>0. 9,r2 >1/3). There were no significant differences (P>0. 05) in 6 haplotypes of ABCA1 gene groups between the LEAD cases and the normal controls. No significant differ-ences (P>0. 05) were found in frequency distribution between the LEAD cases and the normal controls in 8 SNP according to the re-sults of genotype statistics. There was no onset risk of LEAD according to the gene logistic regression analysis. Conclusion:The SNPs of rs10124755, rs2980083, rs1800976, rs4149341, rs2066714, rs2066715, rs2066716, rs2230808 and rs2246293 might not correlate with the susceptibility of LEAD in Han population of Minnan.
