Literature Analysis of 213 ADRs Caused by Ciprofloxacin
10.6039/j.issn.1001-0408.2017.06.17
- VernacularTitle:环丙沙星致不良反应213例文献分析
- Author:
Ming FAN
- Keywords:
Ciprofloxacin;
ADR;
Literature analysis
- From:
China Pharmacy
2017;28(6):780-782
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the characteristics and rules of adverse drug reactions (ADR) of ciprofloxacin,and pro-vide reference for clinical rational drug use. METHODS:Usingciprofloxacinandadverse drug reactionsas key words,the lit-eratures reported in Wanfang database in 1998-2015 were retrieved,the gender,age,route of administration,the original disease, ADR occurrence time,ADR involving organs/systems,the main clinical manifestations,allergies,prognosis and outcome were sta-tistically analyzed. RESULTS:Totally 181 valid literatures were retrieved,involving 213 patients. Male was more than female (57.28% vs. 42.72%);it mainly occurred in the first day(130 cases,61.03%);intravenous injection(179 cases,84.04%)was the main administration route;the main ADR involving organs/systems were systemic damage(71 cases,33.33%)and nervous sys-tem damage(50 cases,23.47%);the main clinical manifestations were anaphylactic shock(65 cases,30.52%),severe cases can cause death (3 cases,1.41%). CONCLUSIONS:The clinic should strictly master the ciprofloxacin indications,use rationally, give close observation to the course of medication,alert the incidence of ADR.
