Quality Evaluation and Index Exploration of the Glycyrrhetinic Acid Lipo-emul
10.6039/j.issn.1001-0408.2017.06.22
- VernacularTitle:甘草次酸脂化乳的质量评价指标探讨
- Author:
Su JIN
;
Shiyuan LI
;
Xiurong ZHANG
;
Fangning CHEN
;
Xiuli WANG
- Keywords:
Glycyrrhetinic acid lipo-emul;
Quality evaluation;
Index;
Drug loading
- From:
China Pharmacy
2017;28(6):800-803
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To provide reference indexs for the quality evaluation of Glycyrrhetinic acid lipo-emul. METHODS:Croy-TEM was used to detect the morphology of Glycyrrhetinic acid lipo-emul,laser nano-particle size analyzer was used to deter-mine the particle size,polydispersity index(PDI)and the zeta potential;UPLC was used to determine the drug loading of its ac-tive ingredient glycyrrhetinic acid;placing 10 d in 30 ℃,then stability was detected. RESULTS:Prepared Glycyrrhetinic acid li-po-emul was clear outline,structural integrity,roundlike and arranged closely;the mean particle size was(245.2±4.29)nm,PDI was (0.054 ± 0.01) and the mean zeta potential was (-6.25 ± 0.54) mV;the average drug loading of glycyrrhetinic acid was (1.25±0.09)mg/mL;the sample with mass concentration of 0.82 mg/mL showed good stability in within 10 d. CONCLUSIONS:Particle size,zeta potential,drug loading and stability can be used as the evaluation index of Glycyrrhetinic acid lipo-emul.
