Efficacy and Safety of Naloxone Combined with Conventional Therapy in the Patients with Pulmonary En-cephalopathy
- VernacularTitle:纳洛酮联合常规治疗对肺性脑病患者的疗效及安全性
- Author:
Zhenggui HAN
;
Wanjun PENG
;
Wenjing WANG
- Keywords:
Naloxone;
AngiotensinⅡ;
Pulmonary encephalopathy;
IL-8
- From:
China Pharmacist
2017;20(2):293-295
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe and analyze the efficacy and safety of naloxone in the treatment of patients with pulmonary encephalopathy. Methods:50 patients with pulmonary encephalopathy were randomly divided into the observation group and the con-trol group. All the patients were carried out continuous oxygen with non-invasive ventilator. The control group was treated with the con-ventional treatment, and the observation group was given naloxone on the basis of conventinal treatment. The treatment course was 7 days. The clinical efficacy, clinical indicators and adverse events of the two groups were observed. Results:The total effective rate of the observation group reached 92. 00%, which was higher than that of the control group without statistical significance (72. 00%, P>0. 05). The levels of pH, PaO2, PaCO2, angiotensinⅡand IL-8 were significantly improved in both groups after the treatment (P<0. 05), and the improvement in the observation group was much better than that in the control group (P<0. 05). The incidence of ad-verse reactions of the two groups after the treatment showed no significant difference (P>0. 05). Conclusion: Early application of naloxone in the treatment of pulmonary encephalopathy can improve the clinical indices significantly with low incidence of adverse reac-tions and high safety, which is worthy of promoted use in clinics.
