Meta-analysis of Effectiveness and Safety of Butylphthalide Capsules Combined with Xueshuantong Injec-tion in the Treatment of Acute Cerebral Infarction
- VernacularTitle:丁苯酞胶囊联合血栓通注射液治疗急性脑梗死疗效和安全性的Meta分析
- Author:
Fengbo WU
;
Guoyou DAI
;
Xiaorong FENG
;
Ting XU
;
Jian LI
- Keywords:
Butylphthalide capsules;
Xueshuantong injection;
Acute cerebral infarction;
Meta-analysis
- From:
China Pharmacist
2017;20(2):314-317
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effectiveness and safety of butyl phthalide capsules combined with Xueshuantong injection in the treatment of acute cerebral infarction (ACI). Methods: Cochrane Library, Medline, Embase, SCI, CBM, CNKI, VIP and Wanfang databases were searched from the building time to May 2016. The enrolled randomized controlled trails were studied by using Cochrane system evaluation methods to perform methodological quality assessment, and RevMan 5. 2 software was used to carry out Me-ta-analysis. Results:A total of 7 randomized controlled trails including 640 patients were enrolled. The results of Meta-analysis dem-onstrated that the effective rate of butylphthalide capsules combined with Xueshuantong injection was superior to that of Xueshuantong injection (RR=1. 33, 95%CI:1. 16-1. 52, P<0. 0001), butylphthalide (RR=1. 45, 95%CI:1. 15-1. 83, P=0. 002) and blank control (RR=1. 31, 95%CI:1. 08-1. 57, P=0. 005). NHISS of butylphthalide capsules combined with Xueshuantong injection was higher than that of Xueshuantong injection (MD=4. 63, 95%CI:3. 38-5. 87, P<0. 00001) and blank control (MD=6. 85, 95%CI:4. 90-8. 80, P<0. 00001). There was no significant difference in adverse drug reactions. Conclusion: Butylphthalide capsules combined with Xueshuantong injection is effective for the therapy of ACI. However, due to the limited quantity and quality of the in-cluded studies, larger scale trials are needed.
