Research Advance in Baicalin in the Prevention and Treatment of Central Nervous System Diseases
- VernacularTitle:黄芩苷防治中枢神经系统疾病的研究进展
- Author:
Qian ZHANG
;
Hao YANG
;
Bo CHEN
;
Jingjing ZHAO
- Keywords:
Baicalin;
Central nervous system;
Neuroprotection
- From:
China Pharmacist
2017;20(2):327-331
- CountryChina
- Language:Chinese
-
Abstract:
As the active ingredient of traditional Chinese medicine Scutellaria baicalensis Georgi, baicalin has a variety of pharma-cological effects. In recent years, baicalin has made significant achievement in the prevention and treatment of central nervous system diseases, such as ischemic brain injury, hemorrhagic brain injury, Parkinson' s disease and spinal cord injury. Numerous studies showed that baicalin could prevent oxygen free radical injury, inhibit nerve cell apoptosis, inhibit inflammation factor expression, pro-tect the mitochondrial energy metabolism, inhibit thrombin receptor and adjust the balance of excitatory amino acid and inhibitory amino acid. Based on the neuroprotective effect of baicalin, it may be a potential medicine for the treatment of central nervous system disea-ses.
