Study Progress in Pharmacokinetics of Proton Pump Inhibitors
- VernacularTitle:质子泵抑制药的药动学研究进展
- Author:
Rongrong CHAI
;
Gefei MENG
;
Jianing DING
;
Quangang ZHU
- Keywords:
Proton pump inhibitors;
Pharmacokinetics;
Gene polymorphism
- From:
China Pharmacist
2017;20(2):331-333
- CountryChina
- Language:Chinese
-
Abstract:
Proton pump inhibitors are H+ /K+-ATPase inhibitors, which can efficiently inhibit gastric acid secretion for a long time. As the latest inhibitory gastric acid drugs, proton pump inhibitors are the best choices for acid-related diseases such as gastroe-sophageal reflux disease, peptic ulcer and gastrointestinal lesions caused by nonsteroidal anti-inflammatory drugs. Proton pump inhibi-tors have significant inhibition to basal gastric acid, night gastric acid and gastric acid secretion caused by gastrin and food stimulation. This article reviewed the pharmacokinetic characteristics of five proton pump inhibitors in domestic market.
