Mechanisms of Diabetogenic Action of Statins
- VernacularTitle:他汀类药物诱发糖尿病的机制综述
- Author:
Shuyuan LIU
;
Yixin SU
- Keywords:
Stains;
Insulin resistance;
Diabetes;
Mechanisms
- From:
China Pharmacist
2017;20(2):337-339
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To alarm the effect of statins on blood glucose, and provide evidence for the rational use of statins in clin-ics. Methods:The recent articles on the effects and potential mechanisms of diabetogenic action of statins were reviewed and summa-rized. Results and Conclusion:Stains, especially lipophilic stains, could increase blood glucose via multiple pathways to induce dia-betes. The potential mechanisms included inhibiting L-type calcium channel, increasing the uptake of plasma-derived LDL-C, inhibi-ting synthesis of ATP and Coenzyme Q10, inhibiting the expression of glucose transporter 4 and inducingβ-cell inflammation, oxidation and apoptosis. Blood glucose should be monitored and adjusted timely when statins are used in clinics.
