Concentration Screening and Antimicrobial Effectiveness of Antimicrobial Preservative for Fluconazole Eye Drop
- VernacularTitle:氟康唑滴眼液抑菌剂浓度筛选和抑菌效力研究
- Author:
Feng LIU
;
Leilei MENG
;
Guoping WANG
;
Ping ZHU
- Keywords:
Fluconazole eye drop;
Bacteriostatis agent;
Bacteriostatis effect;
Benzalkonium
- From:
China Pharmacist
2017;20(2):362-364
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the reasonable amount of bacteriostatis agent in fluconazole eye drop. Methods: According to the method of bacteriostatis effect test in 2015 edition of Chinese Pharmacopoeia (ChP), and Staphyococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candia albicans and Aspergillus niger as the test strains, the bacteriostatis effect of fluconazole eye drop containing 5%, 1%, 0. 3% and 0. 1% benzalkonium chloride was determined. Results: The bacteriostatis effects of fluconazole eye drop containing 5%, 1% and 0. 3% benzalkonium chloride on the five species of tested bacteria complied with the regulations of ChP. The bacteriostatis effects of 0. 1% benzalkonium chloride on Pseudomonas aeruginosa didn't meet the requirements, therefore, 0. 3%was the minimum inhibitory concentration ( MIC) of benzalkonium chloride. Conclusion: The best inhibitory concentration of benza-lkonium chloride is 1%.
