Proficiency Testing for Melting Point Determination of Chemical Drugs in Laboratory
- VernacularTitle:实验室化学药品熔点测定能力验证研究
- Author:
Jing XIONG
;
Yadan LIU
;
Baoming NING
;
Yi LIU
;
Lan HE
;
Xinhua XIANG
;
Jianmin WU
- Keywords:
Proficiency testing;
Chemical drugs;
Melting point;
Robust statistics;
Phenolphthalein;
Saccharin;
Z-score
- From:
China Pharmacist
2017;20(2):386-388
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the capacity and level of melting point determination of chemical drugs in the laboratories par-ticipating in the proficiency testing. Methods:Two test samples were prepared, and the labs volunteered to participate in the proficien-cy testing program ( PTP) . The melting point determination was performed according to the general principle 0612 in part four of Chi-nese Pharmacopoeia (2015 edition), and the results were analyzed by robust statistics and the determination proficiency of the laborato-ries were evaluated by Z-score. Results:The analysis showed that two test samples were homogeneous and stable, which met the re-quirements of the PTP. Totally 31 laboratories had satisfactory results, which accounted for 83. 8%. Conclusion:The majority of the participant laboratories can accurately determine the melting points of test samples, and the information is very helpful to the next profi-ciency testing program.
