Review on Tanshinone Improving Intestinal Barrier Dysfunction in Sepsis

VernacularTitle:丹参酮改善脓毒症肠屏障功能的研究进展
Author: Lvzhao LIAO ; Ronglin JIANG
Keywords: Tanshinone; sepsis; intestinal barrier; phthology and physilology; pharmacological function; review
From: Journal of Zhejiang Chinese Medical University 2017;41(2):171-174
CountryChina
Language:Chinese
Abstract: [Objective] To further study tanshinone role in intestinal barrier dysfunction in sepsis. [Methods] Mainly refer to nearly a decade at home and abroad on tanshinone pharmacological effects, and tanshinone in sepsis, especially the impact on the intestinal barrier dysfunction. [Results] Tanshinone in sepsis, and heart head blood-vessel, anti-tumor and so on in the field of study is more, but improving sepsis of intestinal barrier function in aspects of the study is less, but through tanshinone antibacterial anti-inflammatory, antioxidant, anti platelet aggregation, improve microcirculation, regulate immune function, this paper expounds tanshinone improving sepsis, possible mechanisms of intestinal barrier function. [Conclusion] Tanshinone can improve sepsis pathophysiological process, ischemia oxygen to the tissues and organs and whole body strong inflammatory reaction factors such as the cause of intestinal barrier function is impaired, but for its specific mechanism, further research is needed.