Clinicopathological characteristics of blastic plasmacytoid dendritic cell neoplasm

VernacularTitle:母细胞性浆细胞样树突细胞肿瘤的临床病理学特征分析
Author: Peng CAO ; Xiaoli FENG ; Yuntian SUN ; Wenting HUANG
Keywords: Blastic plasmacytoid dendritic cell neoplasm; Pathology; clinical; Immunophenotype
From: Cancer Research and Clinic 2017;29(2):108-111
CountryChina
Language:Chinese
Abstract: Objective To improve the understanding of blastic plasmacytoid dendric cell neoplasm (BPDCN). Methods The clinicopathological features of 2 cases with BPDCN diagnosed in the Department of Pathology in Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College were analyzed retrospectively. The relevant literatures were reviewed as well. Results The two BPDCN patients were both elderly men with skin nodules. The tumor cells infiltrated diffusely into the whole dermis with sparing the epidermis. BPDCN cells were small to medium size with round or oval irregular nuclei and small nucleoli. Numerous mitoses figures were seen. Immunohistochemistry stain showed that CD4 and CD56 were positive and CD20 and CD3 were negative in the 2 BPDCN cases. Only 1 case was positive for CD123. Conclusions BPDCN is a rare malignant hematopoietic tumor, which is likely to involve skin. The features of morphology and immunophenotype are crucial to make correct diagnosis.