Research Progress in Drug Interactions of Haloperidol
- VernacularTitle:氟哌啶醇药物相互作用的研究进展
- Author:
Kai LEI
;
Yuan HUANG
;
Si ZHANG
;
Guofang HE
;
Dong LIU
;
Xiuhua REN
- Keywords:
Haloperidol;
Drug interaction;
CYP2D6;
CYP3A4;
Dopamine receptor
- From:
China Pharmacist
2017;20(2):334-337
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the drug interactions of haloperidol used in combination with the other drugs to provide refer-ence for safe, reasonable and effective use of haloperidol in clinics. Methods:By retrieving Micromedex? , Pubmed, CNKI and so on, the interactions between haloperidol and the other drugs were summarized and analyzed. Results:The effect of haloperidol was on do-pamine receptors, and haloperidol was mainly metabolized by hepatic cytochrome P450 ( CYP) enzymes. When haloperidol was com-bined with the other drugs, significant interactions of pharmacokinetics and pharmacodynamics were induced by affecting CYP enzymes or dopamine receptor. Conclusion:In clinical practice, the other drugs combined with haloperidol should be reasonable and careful to ensure safe, effective and rational drug use.
