Progress of cellular immunotherapy modified with chimeric antigen receptor targeting epidermal growth factor receptor and its mutants

VernacularTitle:以表皮生长因子受体及其突变体为靶点嵌合抗原受体修饰的细胞免疫治疗研究进展
Author: Wei LI ; Xiujun SONG ; Huijie YU
Keywords: Receptor; epidermal growth factor; Receptor; antigen; Immunity; cellular
From: Cancer Research and Clinic 2017;29(2):138-141
CountryChina
Language:Chinese
Abstract: Epidermal growth factor receptor (EGFR), an important target for tumor targeted therapy, is overexpressed / mutated in the majority of tumors. Immune cells modified by chimeric antigen receptor , including T cells, NK cells and so on, is a new technology in recent years, which has showed an unique advantage in the treatment of malignant tumors. In this paper, the research progress of T cells and NK cells modified with chimeric antigen targeting for EGFR and its mutants will be reviewed.