Hippocampal volume measurement with MMSE score in the application value of cognitive impairment

VernacularTitle:海马体积测量联合 MMSE 评分在认知障碍中的应用
Author: Xiaokun MI ; Qingrui LIU ; Jia WANG ; Gaofeng SHI ; Zhonghui HAN ; Lingling WAN
Keywords: Alzheimer’s disease; mild cognitive impairment; magnetic resonance imaging; hippocampal volume
From: Journal of Practical Radiology 2017;33(2):178-180
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical application value of hippocampal volume (HV)measurement with MMSE score in varying different degrees cognitive impairment.Methods 30 Alzheimer’s disease(AD)patients,30 mild cognitive impairment (MCI)patients and 30 normal controls(NC)were recruited,HV was measured by Siemens Tim-avanto 3.0T super conductance magnetic resonance.Standardized HV and MMSE scores of three groups were comprehensive analyzed.Results The left and right sides and the total HV of AD group were lower than the MCI and the NC group,with significant differences by statistical analysis (P <0.05).The HV had no significant differences between the MCI and the NC group.The MMSE scores of AD group were lower than the MCI and the NC group,with significant differences by statistical analysis (P <0.05),the score had no significant differences between the MCI and the NC group.Conclusion HV measurement with MMSE score would be helpful to provide effective basis for the AD diagnosis,the sensitivity in the diagnosis of MCI is not high.