Clinical characteristics of anti-N-methyl-D-aspartate receptor encephalitis in children and adults
10.3969/j.issn.1002-0152.2016.11.004
- VernacularTitle:儿童和成人抗N-甲基-D-天冬氨酸受体脑炎的临床特征
- Author:
Qin ZHANG
;
Li ZENG
- Keywords:
Anti-N-methyl-D-aspartate receptor encephalitis;
Modified;
Rankin;
Scale;
Clinical characteristics
- From:
Chinese Journal of Nervous and Mental Diseases
2016;42(11):658-663
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare and analyze differences in clinical characteristics, auxiliary examination and im?munotherapy between children with anti-N-methyl-D-aspartate(NMDA) receptor encephalitis and adults. Methods Clinical data was retrospectively collected from 34 cases anti-NMDA receptor encephalitis. All people were divided into the child group and the adult according to the age of onset and the inpatient department. Score of Modified Rankin Scale (mRS) before and after treatment and follow-up period (6 months~24 months) were compared to estimate the neurologi?cal outcomes. Results Data from 34 patients including 19 children and 15 adults was analyzed. Hypoventilation, epilep?sy and status epilepticus were more common in the adult group than in the child. The positive rate of EEG delta brush was higher in child group than in adult group. Two women were complicated by suspicious ovarian teratoma. Intravenous immune globulin was used commonly in the child group, while the plasma exchange or immunosuppressant used common?ly in the adult group. Time of onset to hospital admission and final diagnosis were shorter in the child group than in the adult. Patients requiring ICU were fewer in the child group than in the adult. The scores of mRS were significantly lower in the child group than in the adult at hospital discharge (P<0.05). Conclusion Clinical characteristics is more compli?cated in adults with anti-NMDA receptor encephalitis compared with children including a worse disease severity and a poorer short-term outcome.
