Progress in study of immune response regulated by microRNAs in process of ischemic and hemorrhagic cerebrovascular diseases
10.3969/j.issn.1000-4718.2017.02.030
- VernacularTitle:M icroRNA 调控缺血性及出血性脑血管病过程中免疫反应的研究进展
- Author:
Jue WANG
;
Haiping ZHAO
- Keywords:
Cerebrovascular diseases;
Immunoreaction;
MicroRNAs
- From:
Chinese Journal of Pathophysiology
2017;33(2):369-374
- CountryChina
- Language:Chinese
-
Abstract:
Immune response is one of the main reasons causing neurological deficits in the patients with cere -brovascular diseases , which activates microglia , induces inflammatory reaction and finally results in serious neuronal and endothelial injury .MicroRNAs take part in the regulation of immunoreaction , and simultaneously regulates many target genes and induces faster post-transcriptional regulation to its target genes compared with the traditional transcriptional regu -lation.For providing a basis for the clinical use of microRNAs and applying new therapy , this review mainly focuses on the function and mechanism of microRNAs in the regulation of the immunoreaction caused by cerebrovascular diseases .
