Expression and significance of Mnk2 and eIF4E in esophageal squamous cell carcinoma

VernacularTitle:Mnk2和eIF4E在食管鳞状细胞癌中的表达及其临床意义
Author: Bo ZENG ; Yanfen FENG ; Qitao HUANG ; Jingfu CHEN ; Xin ZHANG ; Xiangqian HAN ; Shuishen ZHANG ; Jianyong ZOU ; Chunhua SU ; Zhenguang CHEN ; Honghe LUO ; Yiyan LEI
Keywords: Esophageal squamous cell carcinoma; MAPK-interacting kinase-2; Eukaryotic initiation factor 4E
From: Chinese Journal of Pathophysiology 2017;33(2):349-352
CountryChina
Language:Chinese
Abstract: AIM: To investigate the expression and significance of MAPK-interacting kinase-2 ( Mnk2 ) and eukaryotic initiation factor 4E ( eIF4E) in the patients with resected esophageal squamous cell carcinoma ( ESCC ). METHODS:The protein expression of Mnk2 and eIF4E in ESCC tissues (98 cases) and normal esophageal tissues (20 cases) were assessed by immunohistochemistry (IHC), and their correlations with clinicopathological features were statisti-cally analyzed.RESULTS:The over-expression rate of Mnk2 and eIF4E was 68.4%(67/98) and 61.2%(60/98), re-spectively.The expression of Mnk2 had a positive correlation with eIF4E (P<0.05).Clinicopathologic analysis showed that Mnk2 expression was significantly correlated with T classification ( P<0.05 ) and clinical stage ( P<0.05 ) .CON-CLUSION:The over-expression of Mnk2 was significantly related to the tumor invasive depth , TNM stages and expression of eIF4E in ESCC.Expression of Mnk2 and eIF4E may have a cooperative formation mechanism in the development of ESCC.