Prescription Screening Test and Inhibitory Rate Experiment of Blumea Gynecological Lotion
10.3969/j.issn.1005-5304.2017.03.021
- VernacularTitle:艾纳香妇科洗液处方筛选及抑菌试验
- Author:
Yan CHEN
;
Kai WANG
;
Quan YANG
;
Yuxin PANG
- Keywords:
Blumea powder;
gynecological lotion;
prescription selection;
bacteriostatic test
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2017;24(3):87-90
- CountryChina
- Language:Chinese
-
Abstract:
Objective To screen the presciption of Blumea gynecological lotion and investigate the inhibitory effect through inhibition rate test; To provide a basis for clinical application. Methods Consumption of Tween-80, SLES, hydrogenated castor oil (RH-40), and clarity of the solution were selected as the evaluation indexes to optimize the solubilizing agents. By using the filter paper method and the inhibition zone size as the evaluation index, the antimicrobial effect on Staphylococcus aureus. Escherichia coli and Candida albicans was studied to screen the best antibacterial agent from 2 g/L GM-BP, 2 mL/L PHMB, 2 mL/L A.SAP. With Blumeapowder dissolution percentage as the evaluation index, orthogonal test was used to screen additives in the lotion. Finally, the bacteriostasis effect and stability of the obtained lotion were investigated in vitro. Results The order of solubilizing effect was RH-40>SLES>Tween-80, and that of inhibition zone size was PHMB>A.SAP>GM-BP. The best prescription as follows:0.6 mg/mL Blumea powder, 0.04 g/mL SLES, 0.01 g/mL CAB-35, 10% propylene glycol. Bacteriostatic rates of Blumea gynecology lotion sample were more than 90%, and bacteriostatic rates remained more than 80% after 3 months. Conclusion The prescription of Blumea gynecology lotion is reasonable and practicable, with simple preparation process, available materials and good inhibitory effect and stability.
