Research Progress in Cell Apoptosis Induced by Shikonin and Signal Pathway of Apoptosis

VernacularTitle:紫草素诱导细胞凋亡及凋亡信号途径研究进展
Author: Yu XIE ; Xiaolong HOU ; Chunlian WU
Keywords: shikonin; apoptosis; signal pathway; review
From: Chinese Journal of Information on Traditional Chinese Medicine 2017;24(3):125-129
CountryChina
Language:Chinese
Abstract: s:Apoptosis, also known as programmed cell death, is a gene controlled active cell suicide process in order to maintain balance of organisms. Apoptosis is mainly mediated through three signal pathways, including the endoplasmic reticulum, mitochondria, and death receptor. As a kind of naphthoquinone compounds and one of the main active ingredients of Lithospermum, shikonin has many biological activities, and its anti-cancer research is recent hot spot. The anti-cancer mechanism of shikonin is closely related with apoptosis and three kinds of signaling pathways. This article reviewed the research progress in apoptosis and signal pathways induced by shikonin.