The efficacy of metformin combined with insulin in the treatment of T1DM in children

VernacularTitle:二甲双胍联合胰岛素治疗儿童T1DM的疗效观察
Author: Jin DONG ; Le HUANG ; Yan ZHAO
Keywords: Metformin; insulin; diabetes mellitus,type 1; child
From: Tianjin Medical Journal 2017;45(2):197-199
CountryChina
Language:Chinese
Abstract: Objective To investigate metformin combined with insulin aspart 30 injection (NovoMix 30) in the treatment of type 1 diabetes mellitus (T1DM) in children and adolescents. Methods A total of 126 T1DM children over 10 years of age were randomly divided into insulin group (A) and insulin + metformin group (B). A group (n=60) was given insulin aspart 30 injection (insulin aspart 30), and B group (n=66) was given the metformin and insulin aspart 30 injection (NovoMix 30). Results The two groups can effectively control blood glucose, but the B group in the blood glucose control time, insulin dosage, the incidence of hypoglycemia, fasting blood glucose and hospitalization time were better than those of A group. There was no significant difference in liver and kidney function before and after oral administration of metformin in B group (P>0.05). Conclusion Metformin combined with insulin is effective and safe in the treatment of children with T1DM.