The detection value of serum alpha -L -fucosidase and alpha fetoprotein 3 in primary hepatocellular ;carcinoma
10.3760/cma.j.issn.1008-6706.2017.03.018
- VernacularTitle:原发性肝癌患者血清α-L-岩藻糖苷酶和甲胎蛋白异质体3检测的意义
- Author:
Youmin HUANG
- Keywords:
Liver neoplasms;
Alpha-L-fucosidase;
Alpha fetoprotein 3
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(3):396-399
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the detection value of serum alpha -L -fucosidase(AFU)and alpha fetoprotein 3(AFP -L3)in primary hepatocellular carcinoma(HCC).Methods 100 patients with primary HCC were enrolled as HCC group,54 cases without HCC were selected as non HCC group,100 healthy persons were selected as healthy group.Serum AFU and AFP-L3 levels in three groups were determined.The serum AFU was measured by the chemical colorimetry,and the AFP-L3 level was determined by chemiluminescence immunoassay.Results The serum levels of AFU in HCC group,non HCC group and healthy group were (71.61 ±3.01)U/L,(11.06 ±2.15)U/L, (8.54 ±1.28)U/L.The serum levels of AFP-L3 in HCC group,non HCC group and healthy group were (30.14 ± 2.93)%,(3.27 ±0.83)%,(2.77 ±0.62)%.The serum levels of AFU and AFP-L3 in HCC group were signifi-cantly higher than those in non HCC group and healthy group (t=13.172,9.770,16.036,7.160,all P<0.01 ). There were no significant differences in serum AFU and AFP-L3 levels between the non HCC group and the healthy group (t=0.761,0.580,all P>0.05).The positive rates of AFU were 87.00%,9.26%and 3.00%in HCC group, non HCC group and healthy group.The positive rate of AFU in HCC group was significantly higher than that in non HCC group and healthy group (χ2 =34.06,57.62,all P<0.01 ).There was no significant difference in the positive rate of AFU between the non HCC group and the healthy group(χ2 =3.81,P>0.05).The positive rates of AFP-L3 were 89.00%,7.41%and 2.00%in HCC group,non HCC group and healthy group.The positive rate of AFP-L3 in HCC group was significantly higher than that in non HCC group and healthy group (χ2 =41.06,77.62,all P<0.01).There was no significant difference in the positive rate of AFP -L3 between the non HCC group and the healthy group (χ2 =3.14,P>0.05 ).There were no significant differences in serum tumor diameter about AFU, AFP-L3(t=0.167,0.579,0.201,0.601,all P>0.05),and there were significant differences about TNM stage, lymph node metastasis,and tumor thrombus (t =6.156,9.105,10.161,8.120,9.770,12.821,all P<0.05). Conclusion Serum AFU and AFP -L3 can not only help the diagnosis of primary liver cancer,but also can determine the prognosis of patients.
