Metabolism of triglyceride in plasma of rabbits with necrosis of femoral head induced by hormone and therapeutic effect of traditional chinese medicine
10.3969/j.issn.1006-5725.2017.02.011
- VernacularTitle:激素诱导下股骨头坏死兔模型血浆中三酰甘油代谢及中药干预作用的研究
- Author:
Kaiyun CHEN
;
Xiuhua LV
;
Zhen LIU
;
Hongxin LIU
;
Wei LIU
;
Ping AI
;
Xuefeng YU
- Keywords:
Femoral head necrosis;
Steroid;
Traditional Chinese medicine;
Lipid metabolism
- From:
The Journal of Practical Medicine
2017;33(2):206-209
- CountryChina
- Language:Chinese
-
Abstract:
Objective Toinvestigate the metabolic characteristics of triglyceride (TG) in the plasma of rabbitswith steroid?induced osteonecrosis of the femoral head and the therapeutic effect of Gushiling Capsule. Methods Rabbit model of femoral head necrosis induced by hormone was established. The level of plasma TG was detected by HPLC/MS and the relationship between the changes of plasma TG level and local histomorphology of femoral head was analyzed. Results Compared with the normal control group, significant changes of plasma TG levels were observed in the model group, the traditional Chinese medicine group and the western medicine group at each time point (P<0.01). However, no significant difference was found between the traditional Chinese medicine group and the western medicine group. Compared with the model group, only a small amount of high signal joint imaging and central signal of the femoral head were found by the MRI examination in the traditional Chinese medicine group and the western medicine group. Pathology assay results showed the degree of femoral head osteonecrosis in the Chinese medicine group was milder than that in the Western medicine group. Conclusion Gushiling Capsule and western medicine Simvastatin have the similar effect of reducing plasma TG, which may be one of the mechanisms underlying Gushiling Capsule preventing steroid?induced femoral head necrosis.
