Relationship between interleukin-17 gene polymorphisms and outcomes of hepatitis B virus infection in He-bei Han population
10.3969/j.issn.1006-5725.2017.02.016
- VernacularTitle:河北汉族人群白细胞介素-17血清表达水平及基因多态性与乙型肝炎病毒感染的关系
- Author:
Peiyuan HE
;
Zhiping HOU
;
Chunqing WANG
;
Chunying YIN
;
Yanling WANG
;
Bingqing LI
- Keywords:
Interleukin-17;
Gene polymorphism;
Hepatitis B virus;
Hebei Han population
- From:
The Journal of Practical Medicine
2017;33(2):227-230
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the polymophisms of interleukin?17 (IL?17)?197A/G and the outcomes of hepatitis B virus (HBV) infections. Methods The polymorphism of genotypes and al?leles of IL?17?197A/G in 222 chronic HBV infected patients and 88 HBV infected ones as controls. The contains of serum HBV DNA were detected using PCR combined with DNA amplification in vitro, serum IL?17 expression was detected with ELISA and genotype and allele frequency of IL?17?197A/G locus was detected by Beckman SNP kit. Results There was a significant difference in the serum IL?17 expression (F=158.1, r2=0.61, P<0.000 1) among all the groups. For IL?17?197A/G, there were significant differences for the comparison between the two groups, and the frequency of AA genotype was 47.72%in liver cirrhosis group. Moreover, the highest frequency of GG was in HBV clear?ance group (74.81%);and the lowest group was in chronic HBV liver cirrohosis group (19.05%). Conclusion IL?17?197A/G AA genotype and allele might be associated with susceptibility of HBV infection in Han population in Hei?bei Province.
