Progress on radionuclide-labeled small peptides in targeting tumor angiogenesis
10.3969/j.issn.1000-8179.2017.02.124
- VernacularTitle:核素标记小分子多肽靶向诊治肿瘤新生血管的应用研究进展
- Author:
Xiaoxi PANG
;
Yan HUO
;
Rongfu WANG
- Keywords:
tumor angiogenesis;
RGD peptide;
RRL;
αvβ3
- From:
Chinese Journal of Clinical Oncology
2017;44(2):68-72
- CountryChina
- Language:Chinese
-
Abstract:
Early diagnosis and precision medicine generally show significant differences in the prognosis of patients with carcinoma. Angiogenesis not only plays a key role in tumor pathophysiology but also acts as an important drug target. Peptides with specific se-quences can target specific molecules on the endothelial cellular membrane during tumor angiogenesis. Radionuclide-labeled molecu-lar probes exhibit many advantages in oncotherapy. This article focuses on the progress of radionuclide-labeled RGD and RRL in radio-immunoimaging and radioimmunotherapy targeting tumor angiogenesis.
