Research progress on lncRNAs in haematopoietic and lymphoid tissue tumors

VernacularTitle:lncRNAs在淋巴造血系统肿瘤中的研究进展
Author: Yi PAN ; Baocun SUN
Keywords: long noncoding RNAs; haematopoietic and lymphoid tissue tumors; biomarkers
From: Chinese Journal of Clinical Oncology 2017;44(2):96-99
CountryChina
Language:Chinese
Abstract: Long noncoding RNAs (lncRNAs) are non-protein coding transcripts longer than 200 nucleotides. Most lncRNAs have pro-nounced oncogenic effects associated with tumorigenesis and progression, promoting the proliferation, migration, invasion, and me-tastasis of tumor cells. The specific lncRNAs expression in particular types of cancers makes them promising diagnostic and prognostic biomarkers. Currently, studies on lncRNAs expression, functions, and mechanisms have attracted considerable attention in cancer re-search. However, these studies mainly focus on epitheliogenic malignant tumors. In this review, we outline the current state of infor-mation on lncRNAs and research progress on its role in haematopoietic and lymphoid tissue tumors.