Nitric oxide bioavailability dysfunction and atherosclerosis
- VernacularTitle:一氧化氮生物利用度失调与动脉粥样硬化
- Author:
Jingyi CHEN
;
Zixin YE
;
Shuya CUI
;
Xiufen WANG
;
Fenfang HONG
;
Shulong YANG
- Keywords:
atherosclerosis;
endothelial dysfunction;
nitric oxide;
nitric oxide synthase;
NO bioavailability
- From:
Basic & Clinical Medicine
2017;37(2):251-255
- CountryChina
- Language:Chinese
-
Abstract:
Endothelial dysfunction was closely related with AS , NO bioavailability ( production and utilization of endothelial NO ) was decreased by oxidative stress , lipid infiltration , inflammatory factor expression , vascular tone alteration and so on , which play an important role in endothelial dysfunction .Enhanced arginine , activityand asym-metric dimethylarginine together with increased hyperhomocysteinemia all promote AS by intervening NO bioavail -ability.Diabetes mellitus, obesity, chronic kidney disease , smoking and so on also involved in AS via influencing NO bioavailability and NO level .
