Research progress in molecular mechanism of hematopoietic stem cell injury induced by ionizing radiation
- VernacularTitle:电离辐射诱导造血干细胞损伤的分子机制研究进展
- Author:
Lianying FANG
;
Yan WANG
;
Chang XU
;
Liqing DU
;
Qin WANG
;
Qiang LIU
- Keywords:
ionizing radiation;
hematopoietic stem cell;
apoptosis;
differentiation;
senescence
- From:
Basic & Clinical Medicine
2017;37(2):256-260
- CountryChina
- Language:Chinese
-
Abstract:
Hematopoietic stem cell ( HSCs) injury induced by ionizing radiation ( IR) is the primary cause of death after exposure to ionizing radiation .The mechanisms of inducing HSCs damage include induction of HSCs apoptosis via the P53-Puma pathway;promotion of HSCs differentiation via the activation of the G-CSF/Stat3/BATF-depend-ent differentiation checkpoint;induction of HSCs senescence via the ROS-P38 pathway; and damage to the HSCs niche.Recent researches provide a basis for the prevention and treatment of bone marrow suppression caused by ionizing radiation .
