Nedaplatin plus fluorouracil combined with radiotherapy compared with cisplatin combined with radio-therapy in the treatment of locally advanced nasopharyngeal carcinoma
10.3969/j.issn.1006-5725.2017.02.004
- VernacularTitle:奈达铂加氟尿嘧啶同期放疗与顺铂同期放疗治疗局部晚期鼻咽癌的疗效比较
- Author:
Xionghui MA
;
Xiaohui WANG
;
Liangchang XIU
;
Yunfei XIA
- Keywords:
Locally advanced nasopharyngeal carcinoma;
Nedaplatin;
Cisplatin;
Concurrent chemotherapy
- From:
The Journal of Practical Medicine
2017;33(2):181-184
- CountryChina
- Language:Chinese
-
Abstract:
Objective Combination of chemotherapy regimens and chemoradiotherapy to the curative effect of locally advanced nasopharyngeal carcinoma is unclear. The carcinoma radiotherapy adverse reaction and curative effect were investigated in nedaplatin plus fluorouracil in the same period radiotherapy(Group NF)compared with cisplatin(DDP)in the same period (Group DDP)in the treatment of locally advanced nasopharyngeal. Method Patients with locally advanced(ⅢandⅣB)nasopharyngeal carcinoma(NPC)in Sun yat?sen university cancer hospital were enrolled and divided into two groups:222 cases in the NF group and 165 cases in the DDP group. The adverse reaction,5?year progression?free survival(PFS)and overall survival(OS)for 5 years were evaluated in two groups. Results The 5?year PFS in the NF and DDP group was 85.13%and 82.42%,respectively, with no significant difference. The 5?year OS in the NF and DDP group was 85.58% and 82.42%,respectively, with no significant difference. The proportion of oral mucositis in the NF group was significantly lower than that in the DDP group. Conclusion Nedaplatin plus fluorouracil radiation therapy has similar curative effect ,adverse reaction with cisplatin plus the same radiation therapy in the treatment of locally advanced nasopharyngeal carcinoma.
