Correlation between preoperative NLR, PLR, and RDW and clinical pathological param-eters in gastric cancer patients
10.3969/j.issn.1000-8179.2017.02.231
- VernacularTitle:胃癌患者术前NLR PLR RDW值与病理参数的关系
- Author:
Jing JIA
;
Ying CHEN
;
Lu LIN
;
Lin WANG
;
Dedong CHEN
;
Xingming YE
;
Yan CHEN
- Keywords:
gastric cancer;
TNM stage;
neutrophil-to-lymphocyte ratio;
platelet-to-lymphocyte ratio;
red cell distribution width
- From:
Chinese Journal of Clinical Oncology
2017;44(2):78-82
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the association between preoperative neutrophil–lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red cell distribution width (RDW) and the tumor pathological features in gastric cancer (GC) patients. Methods: We re-viewed the records of 434 patients from 2012 to 2014 in Fujian Cancer Hospital. All patients were admitted to the hospital for the first time, and no patients received any cancer-specific pretreatment. For comparison, 309 age-and gender-matched healthy individuals who underwent annual physical examination at the hospital and 342 patients with chronic atrophic gastritis were enrolled. Results:GC patients had higher NLR, PLR, and RDW than the controls (P<0.000 1). Elevated NLR, PLR, and RDW were associated with the develop-ment of tumor stages as indicated by the Kruskal-Wallis analysis. However, no similar association was observed between the tumor dif-ferentiation grade and location and those three markers. Multivariate regression analysis further revealed that both NLR and PLR were independent predicting factors for either the tumor TNM or T stage (P<0.000 1). ROC curve analysis showed that NLR and PLR had a certain diagnostic effect on the preoperative T staging of GC. Conclusion:The preoperative NLR and PLR levels are closely correlated with the tumor TNM stages in GC patients. Both these parameters have potential values as markers to assist either in early diagnosis or preoperative tumor stage evaluation in GC.
