Influence of short-term intensive insulin therapy on plasma concentration of lipoprotein-associated phospholipase A2 and secretory phospholipase A2 in newly diagnosed type 2 diabetic patients

VernacularTitle:短期胰岛素强化治疗对新诊断2型糖尿病患者血浆脂蛋白相关性磷脂酶A2及分泌型磷脂酶A2水平的影响
Author: Xiuhong LIN ; Mingtong XU ; Lifang MAI ; Juying TANG ; Xiaoyi WANG ; Yan LI ; Li YAN
Keywords: Diabetes mellitus,type 2; Phospholipase A 2
From: Chinese Journal of Internal Medicine 2017;56(2):127-129
CountryChina
Language:Chinese
Abstract: [Summary] The aim of the study was to explore the effect and its clinical relevance of short -term intensive insulin treatment on plasma concentrations of lipoprotein-associated phospholipase A 2 ( Lp-PLA2 ) and secretory phospholipase A2(sPLA2) in newly diagnosed type 2 diabetes mellitus (T2DM).Ninety newly diagnosed T2DM patients were recruited and received continuous subcutaneous insulin infusion (CSII) for about 2 weeks.After CSII, sPLA2 levels [173.78 (80.95, 278.09) μg/L] were significantly decreased compared with the levels before [219.33 (130.03, 337.30) μg/L], P <0.01, while no statistic significant changes could be viewed in Lp-PLA2 levels.Correlation analysis showed that the changes of Lp-PLA2 and sPLA2 were both positively correlated with the changes of homeostasis model assessment of insulin resistance(HOMA-IR)after CSII (r=0.537,0.493 respectively, all P<0.05).The Lp-PLA2 and sPLA2 level reduction after CSII might help to protect the patients from diabetic macroangiopathy . Trial registration Chinese Clinical Trial Registry , ChiCTR-TRC-10001618.