Expression of miR-2 2 1 and miR-2 2 2 in Papillary Thyroid Carcinoma Tissues and Its Clinical Significance
10.3969/j.issn.1671-7414.2017.01.012
- VernacularTitle:miR-221与miR-222在甲状腺乳头状癌组织中的表达及临床意义
- Author:
Guirong LI
;
Qingxia ZHAO
;
Bin SONG
;
Jie LIU
;
Jin ZHANG
;
Shidong LI
;
Xiangli HAN
;
Hui LIU
;
Wen ZHANG
- Keywords:
papillary thyroid carcinoma;
miR221;
miR-222;
pathology
- From:
Journal of Modern Laboratory Medicine
2017;32(1):41-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expressions of miR-221 and miR-222 in papillary thyroid carcinoma (PTC),and relativi-ties with clinical pathological features.Methods Samples from patients of PCT (43 cases),nodular golter(21 cases),and para-carcinoma thyroid tissues(14 cases),78 cases in total (from 06/2015 to 05/2016,Shaanxi Provincial People’s Hospital) were collected.Real time-PCR tests were carried out,then analyzed in relation to clinical pathology features,and statistical a-nalysis was used to evaluate the results.Results The expressions of miR-221 and miR-222 were significantly higher in PTC (11.54±3.37,10.67±2.45)than in nodular golter (3.21±1.12,2.89±1.23)and normal thyroid tissue (2.02±0.76, 1.98±0.34)(t=3.62,3.25;3.27,3.01,all P<0.05),which were significantly related with Regional lymph node metasta-sis,tumor invasion coated,distant metastasis and clinical stage (P<0.05),while not related with the gender,age,or size of the tumor of the patients (P>0.05),and no differences were found in nodular golter and in normal thyroid tissue (t=0.91, 0.79,P>0.05).Conclusion miR-221 and miR-222 could be considered as a specific molecular marker of PTC,may play an important role in the diagnosis and treatment on PTC.
