Application of Milk Protein Challenge Test and Serum IgE Antibody Detection in Children with Milk Protein Allergic Diseases
10.3969/j.issn.1671-7414.2017.01.032
- VernacularTitle:牛奶蛋白激发试验与血清IgE抗体检测在牛奶蛋白过敏患儿诊断中的应用
- Author:
Jingjing YAO
;
Fei YANG
- Keywords:
milk protein;
allergic;
challenge test;
digestive tract;
IgE antibody
- From:
Journal of Modern Laboratory Medicine
2017;32(1):117-120
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application effects of milk protein challenge test and serum specific IgE antibody de-tection in children with milk protein allergic diseases.Methods 76 cases of children with milk protein allergic diseases of North Hospital of the People’s Hospital in Urumqi City from January,2013 to December,2015 were treated with milk pro-tein challenge test.The clinical characteristics,results of milk protein challenge test and serum IgE antibody detection,and the value change of routine blood indexes were analysed and compared.Results Diarrhea and hematochezia were the most common clinical features,vomiting,hematemesis and abdominal distention were rare.47 cases (61.8%)showed positive re-sults in milk protein challenge test,and 29 cases (38.2%)showed negative results.42 cases of positive children had delayed allergy,and 5 cases showed rapid allergy.Compared with the negative group,the positive rate of serum specific IgE antibody in positive group didn’t change obviously,the difference was not statistically significant (14.9% vs 6.9%,χ2=0.466,P>0.05).The neutrophil count in positive group was higher after challenge than that of before challenge (t=2.480,P<0.05). The number change of blood cell,neutrophil and platelet in positive group were no statistical differences compared with those in negative group (t=0.500,1.395,0.296,all P>0.05).Conclusion Diarrhea and hematochezia were the most commom disease of digestive tract in children with milk protein allergic diseases.It is necessary to perform milk protein challenge test in clinical practice,however,serum specific IgE antibody is not considered as its diangnosis basis.
